How to get date rape drug

What could be the appeal of a drug that makes a person animalistic? [closed]

If realism is important in your novel, you should keep in mind that all areas of the brain, although made up of numerous "functions" (for example, the Broca area and the Wernicke area, are involved in providing language, the hippocampal shapes) Part of the substrate for the formation of emotional memory, etc., largely follows the same processing paradigm - input received; Do things; Press outputs.

The elements of this paradigm also follow a predictable physiology - that is, the actual type of neurotransmitter may vary (dopamine, serotonin, GABA, etc.), but how it works is the same: neurotransmitters (regardless of type) collect in vesicles and move around in Towards the neural terminal in these vesicles, which fuses with the terminal wall, thereby draining the neurotransmitter contents into the synaptic gap. After a pause, a "pump" soaks up the remaining channels (called resumption); The other transmitters in this collection bind to certain receptor channels on the dendrites of the recipient neuron. One important note: this does not change for the different areas of the brain.

All controlled substances act either as agonists (accelerating this flow) or as antagonists (interrupting the flow). Accordingly, your drug is unable to isolate functional areas (e.g., decision-making and memory formation) because neurotransmitters are largely shared by the neural functions. The next thing we would get is something similar to cocaine - which antagonizes the reuptake of dopamine and causes heightened states of alertness due to dopaminergic hyperflow in the synaptic gap.

Another consideration: In order for your medicine to work, a significant part of the brain needs to be “turned off”. The brain wasn't designed in a single architectural session. It is the product of 3.5 billion years of small, incremental changes. As a result, there are ancient parts of the brain (including the misnomer "Lizard Brain") that are typically located in the core of the brain and near the trunk. The anatomically modern neural areas are usually closer to the surface of the brain and extremities (for example, the lower frontal gyrus, which is at the tip of the prefrontal cortex, is involved in the go \ no-go phase of our decision-making process ). In order for your drug to work, certain modern neural areas such as the primary visual cortex must remain functional (or the user experiences vivid visual effects of all kinds, resulting in them not being a very capable "animal").

The alternative to this knock-out is to give the old neural areas an unfair advantage (the how remains elusive) - these areas are less complex than their modern equivalents and therefore can (as a rule of thumb) complete their less complex tasks in shorter time. Therefore, it is possible to "scare" a person with something as absurd as a "gorilla in the house" -type prank. The modern parts of the brain can calculate that gorillas don't belong in your house and that jumping out on you is a prank. However, the old paths do not do such contextual calculations and respond to "tall, furry, coming very quickly". The old parts of the brain are therefore able to perform their function (which triggers the fight / flight reflex) earlier than the modern pathways, and ... they emit a species-specific voice alert (also known as a girl's cry), hands fly in defense high, the face contorts expectantly, the upper body shrinks back from the threat - a classic early flight reaction.

Why should someone find this effect pleasant? Some transmitters are connected to the “reward system” (e.g. serotonin - involved in fun activities such as eating, sex, etc.), others to an increased awareness (pleasant in itself). There are additional effects, such as the release of endorphins (the brain's morphine) after certain stresses (which among other things cause the knees to weaken and analgesia), and these are also very pleasant.

The answer to your question is: construct a (realistic) reward for a chemical that, in the medium term, causes physical changes to some type of ion channel - this makes the substance addictive and requires significant rehabilitation to kick (read on ) on the medium to long-term effects of heroin).

For something this specialist needs, you must read on if you want the hope of staying between the lines. I suggest that one of the works of VS Ramachandran, Eric Kandel, Steven Pinker, Motoy Kuno (his work entitled The synapse ), David Eagleman, etc. Ramachandrans tell-tale brain as a solution offers an interesting (not chemical) perspective - think of implants. Enjoy.

Joe Bloggs

+1 for further reading!

Pojo type

Recent advances in neurochemistry have completely debunked the "resumption" theory. This has made a hole in our understanding of neurochemistry very visible and explains why drugs based on this theory often have unpredictable effects. The last thing I heard was that they were still figuring out what the metabolic pathways believed to be related to resumption really are.


@ Pojo-Guy - thanks for the hint. I admit that I am not as up to date as I used to be in this rapidly evolving area. Do you have references on this, preferably on a website that supports Shibboleth access?

Pojo type

I'll hunt around and see if I can find the item again. Unfortunately, Google is good at finding popular reading, but not so good at finding in-depth technical documents.